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Sustained Release of SprayDried Combination Dry

Sustained Release of SprayDried Combination Dry

(PDF) Sustained release of spray-dried combination dry ...

2011-9-23  Sustained release of spray-dried combination dry powder inhaler formulation for pulmonary delivery September 2011 Asian Journal of Pharmaceutical and Clinical Research 4(4):112-118

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(PDF) Sustained Release of Spray-Dried Combination Dry ...

Academic Sciences Asian Journal of Pharmaceutical and Clinical Research Vol. 4, Issue 4, 2011 ISSN - 0974-2441 Research Article SUSTAINED RELEASE OF SPRAY-DRIED COMBINATION DRY POWDER INHALER FORMULATION FOR PULMONARY DELIVERY NUTAN SHAH*, MANISH KONDAWAR, ROHIT SHAH AND VISHAL SHAH Appasaheb Birnale College of Pharmacy, Sangli 416416,

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Academic Sciences Asian Journal of Pharmaceutical and ...

sustained release of spray-dried combination dry powder inhaler formulation for pulmonary delivery . research article . nutan shah*, manish kondawar, rohit shah and vishal shah

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Sustained release of etanidazole from spray dried ...

2002-6-17  Etanidazole, a kind of radiosensitizer, was encapsulated in the spray-dried microspheres using biodegradable polymer PLGA 65:35 as the carrier for controlled release applications. Two non-halogenated solvents, e.g., ethyl acetate (EA) and ethanol, were tested to modify the properties of microspheres prepared by the commonly used solvent ...

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Sustained delivery by leucine-modified chitosan spray ...

This study investigated the formulation and evaluation of respirable spray-dried combination powders showing the sustained release of two chemically distinct therapeutic agents.

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Development of Sustained Release Oseltamivir Phosphate Dry ...

2020-1-1  The spray-dried product was further characterized for various pharmaco-technical, in-vitro and in-vivo parameters. RESULTS:OP-DPI showed a burst release of 49% within 15 min further sustaining the drug release up to 9 hrs.

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Comparison of Phospholipid-Based Particles for Sustained ...

2019-11-21  liposomes and spray-dried dry powder formulations) on drug delivery, safety, and tolerability in bronchiectasis patients. Despite the differences in formulation design, the two formulations deliver comparable ciprofloxacin doses to the lungs, and have similar aerodynamic particle size distributions and kinetics of drug clearance from the lungs.

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Spray freeze drying: Emerging applications in drug ...

2019-4-28  Spray freeze drying yields particles of sizes and densities that show higher stability in the lungs, nasal mucosa, intestine, and skin, as compared to other drying technologies. These particles also possess the vital trait of sustained release and specificity through various delivery routes as compared to conventional drying techniques.

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Microparticles for sustained release of water-soluble drug ...

Microparticles for sustained release of water-soluble drug based on a containment, dry coating technology Controlled release microparticles in a sub-gram-scale batch were fabricated using a ball mill, dry coating technique, to coat the water-soluble core material.

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(PDF) Preparation and characterization of spray-dried ...

The optimum sustained-release parenteral formulation was the suspension of the spray-dried microparticles of methylcellulose and granisetron hydrochloride (ratio 5:1) in the mixture of medium ...

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Formulation and Optimisation of Sustained Release Spray ...

Formulation and Optimisation of Sustained Release Spray-Dried Microspheres of Glipizide Using Natural Polysaccharide Mangesh Bhalekar IntroductionTamarind seed polysaccharide (TSP) is a galactoxyloglucan obtained from endosperm of seeds of the tamarind tree (Tamarindus indica), also called xyloglucan (XG), which is a seed gum with potential ...

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Formulation and Evaluation of Spray-Dried Esomeprazole ...

sustained release properties with 99.8 % of drug released at the end of 12 h. Conclusion: Microspheres prepared using locust bean and xanthan gums can be used as a sustained release delivery system for esomeprazole magnesium. Keywords : Spray drying, Microspheres, Esomeprazole magnesium, Sustained release

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PVP co-spray drying and physical mixing with PVAc and ...

2017-6-6  (2016) Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP, Drug Development and Industrial Pharmacy, 42:2, 270-279, DOI: 10.3109/03639045.2015.1047848

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Sustained release of insulin from sodium hyaluronate based ...

2003-9-4  Sustained release of insulin from sodium hyaluronate based dry powder formulations after pulmonary delivery to beagle dogs. ... (>7 fold), AUC/dose (5 fold) and Tmax (by a factor of 3) when compared to spray dried pure insulin. Our results demonstrate the potential of HA-based dry powder drug delivery systems in the pulmonary controlled release ...

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Sustained Release Ziprasidone Microparticles Prepared by ...

2019-12-19  The purpose of this study was to develop and evaluate a new formulation of ziprasidone (ZIP) for improved fasted state absorption and sustained drug release. ZIP solid dispersions were produced via spray drying using Soluplus®, an amphiphilic polymer, as the solubility enhancer. Physicochemical analysis proved that ZIP presented at amorphous state in the spray-dried

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Sustained-release microparticle dry powders of ...

The purpose of this study was to design inhalable sustained-release nanoparticle-in-microparticles, i.e. nano-embedded microparticles, for the lung delivery of chloramphenicol or thiamphenicol as aerosols. The palmitate ester prodrugs of the two antibiotics were used to prepare PLGA-based nanopartic

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Formulation and Evaluation of Novel Spray-dried Alginate ...

2015-6-10  In vitro drug release study Drug release from spray dried RAM with and with-out bCD was carried out using modified dissolution method.20,21 The simulated lung fluid of phosphate buffer pH 5.2 was prepared by adding 200 µg/mL ascorbic acid as an antioxidant to prevent oxidative degradation. The microspheres equivalent to 50 mg of drug was suspended

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Dry sustained release theophylline oral formulation - Key ...

A dry sustained release oral dosage formulation of theophylline and a method of orally administering theophylline is disclosed. The oral formulation is comprised of a capsule which includes upper and lower parts which are connectible and easily separable from each other, and

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Spray drying pharmaceuticals - European Pharmaceutical

2011-12-13  By definition, spray drying is the transformation of a feed from a fluid state into a dried particulate form by spraying the feed into a hot drying medium 1.The drying medium is typically air, but an inert gas, e.g. nitrogen, can be employed when the

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Surface Composition and Aerosolization Stability of an ...

2020-10-9  This study aims to understand the impact of spray drying nozzles on particle surface composition and aerosol stability. The combination formulations of colistin and azithromycin were formulated by 2-fluid nozzle (2 N) or 3-fluid (3 N) spray drying in a molar ratio of 1:1. A 3-factor, 2-level (23) factorial design was selected to investigate effects of flow rate, inlet temperature and feed ...

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Formulation and Evaluation of Spray-Dried Esomeprazole ...

sustained release properties with 99.8 % of drug released at the end of 12 h. Conclusion: Microspheres prepared using locust bean and xanthan gums can be used as a sustained release delivery system for esomeprazole magnesium. Keywords : Spray drying, Microspheres, Esomeprazole magnesium, Sustained release

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Chitosan-based spray-dried respirable powders for ...

In this study, we describe the preparation of highly dispersible dry powders for pulmonary drug delivery that display sustained drug release characteristics. Powders were prepared by spray-drying 30% v/v aqueous ethanol formulations containing terbutaline sulfate as a model drug, chitosan as a drug release modifier and leucine as an ...

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PVP co-spray drying and physical mixing with PVAc and ...

2017-6-6  (2016) Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP, Drug Development and Industrial Pharmacy, 42:2, 270-279, DOI: 10.3109/03639045.2015.1047848

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Formulation and Characterization of Spray-Dried Powders ...

Spray-drying is a technology for the preparation of drugs that can be delivered to lung via a dry powder inhaler. The results showed an appropriate particle size and shape for the pulmonary delivery. The aerosol behaved a sustained-release profile while VCR solution released rapidly within 10 h.

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Parenteral sustained release of peptides and proteins ...

Spray dried hGH, hyaluronate, lecithin microparticles J. Pharm. Sci. 105, 2016, 613-622 ... ‣Large potential within sustained release of peptides and proteins which could be realized with novel technologies. 21 ... half-life extension in combination with microencapsulation or in

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Preparation and In Vitro Evaluation of Budesonide Spray ...

2016-12-21  Spray dried powders that exhibit sustained drug release properties may be generated through inclusion of drug release modifiers such as chitosan [11]. Chitosan, a polysaccharide derived from deacetylation of naturally occurring polymer chitin, is a promising excipient that can be employed in a wide range of applications, including

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Spray-dried plasma: A post-traumatic blood 'bridge' for ...

2021-7-17  Spray drying uses a combination of heated, clean dry air, variable plasma flow rates, pressure, and specialized spray nozzles to atomize the plasma and rapidly remove the water fraction. The spray drying process, properly con-trolled, yields intact dry plasma proteins with low residual moisture. The final product contains about 1% residual water.

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Spray Drying – All About Drugs

Both enteric release and sustained release can be achieved. Spray drying allowed the rapid formation of theophylline polymer micro particles without exposing the material to high temperatures. Aerosol formulation. Salbutamol sulphate particles, for use in dry powder aerosol formulation, were prepared by spray drying, using a Mini spray

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Modified release of beclometasone dipropionate from ...

Dry powders for inhalation were prepared by spray drying a 30% v/v aqueous ethanol formulation containing beclometasone dipropionate (BDP), lactose, leucine and chitosan (low, medium or high molecular weight (MW), or combinations thereof). Following physical characterisation of the powders, the aerosolisation and dissolution properties of the powders were investigated using Multi-Stage Liquid ...

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US4587118A - Dry sustained release theophylline oral ...

A dry sustained release oral dosage formulation of theophylline and a method of orally administering theophylline is disclosed. The oral formulation is comprised of a capsule which includes upper and lower parts which are connectible and easily separable from each other, and a plurality of micropellets present in the capsule. The micropellets provide sustained release of theophylline when ...

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